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Trixilem (Methotrexate)

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Trixilem is a type of medicine called an immunosuppressant. It slows down your body's immune system and helps reduce inflammation. It is used to treat inflammatory conditions, including: rheumatoid arthritis.

Other names for this medication:
Alltrex, Beltrax, Biotrexate, Caditrex, Carditrex, Cytotrex, Dermotrex, Folitrax, Imutrex, Merex, Methocip, Methorex, Methotrexate, Metorex, Metrex, Mexate, Neotrexate, Nidtrex, Oncotrex, Onotrex, Plastomet, Remtrex, Rextop, Roxate, Tevatrex, Throtex, Trixilem, Vibzi, Zexate

Similar Products:
Avapro, Revia, Imuran, Leukeran, Myambutol, Nuvigil, Citmol, Carbasma, Rogaine, Bactropin, Femoston, Terol, Clinsol, Avomine, Epraz, Amiocar,

Also known as: Methotrexate


Trixilem SR is a nonsteroidal anti-inflammatory drug (NSAID).

Trixilem SR is used to treat moderate to severe osteoarthritis, rheumatoid arthritis, gouty arthritis, or ankylosing spondylitis. This medicine is also used to treat shoulder pain caused by bursitis or tendinitis.

Extended-release Trixilem SR (Trixilem SR) should not be used to treat gouty arthritis.


The Trixilem dosage your doctor prescribes will depend on several factors. These include:

  • the type and severity of the condition you’re using Trixilem to treat
  • your age
  • other medical conditions you may have
Typically, your doctor will start you on a low dosage and adjust it over time to reach the dosage that’s right for you. They’ll ultimately prescribe the smallest dosage that provides the desired effect.

The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to suit your needs.

Dosage for narcolepsy and sleep apnea

For daytime sleepiness caused by narcolepsy or obstructive sleep apnea, the typical dosage is 200 mg once a day in the morning. Higher doses are sometimes used, up to 400 mg daily. However, these doses may not be any more effective than 200 mg daily.

Dosage for shift work sleep disorder

For excessive sleepiness due to shift work sleep disorder, the typical dosage is 200 mg taken about one hour before the start of your work shift.

Dosage for people with liver problems

If you have severe liver problems, your doctor will likely prescribe a lower dosage. The recommended dosage for people with this condition is typically 100 mg daily.

Dosage for seniors

Seniors may be more sensitive to the effects of Trixilem, especially side effects. If you’re over 65 years of age, your doctor may prescribe a lower dosage.

What if I miss a dose?

If you miss a dose, take it as soon as you remember. Remember that Trixilem will keep you awake, so don’t take it unless you plan to be awake for several hours. If it’s close to your bedtime, skip the missed dose and take it the next day at the normal time.

Never try to catch up by taking two doses at a time. This can cause dangerous side effects.

Will I need to use this drug long-term?

Yes, Trixilem is usually taken long-term by people with narcolepsy or sleep apnea. These are chronic conditions that often require long-term treatment to improve symptoms of daytime sleepiness.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Trixilem are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Using Trixilem may increase your risk of developing prostate cancer. Your doctor will perform tests to make sure you do not have other conditions that would prevent you from safely using Trixilem.

Before taking Trixilem, tell your doctor if you have ever had an allergic reaction to this medication, or to a similar medicine called finasteride (Propecia, Proscar).

Trixilem should never be taken by a woman or a child. Dutasteride can be absorbed through the skin, and women or children should not be permitted to handle Trixilem capsules. Although this medicine is not for use by women, this medication can cause birth defects if a woman is exposed to it during pregnancy. Trixilem capsules should not be handled by a woman who is pregnant or who may become pregnant. If a woman accidentally comes into contact with this medication from a leaking capsule, wash the area with soap and water right away.

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