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Valop (Divalproex)

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Valop is used to treat seizure disorders, certain psychiatric conditions (manic phase of bipolar disorder), and to prevent migraine headaches. It works by restoring the balance of certain natural substances (neurotransmitters) in the brain.

Other names for this medication:
Biproate, Desval, Dicorate, Diproex, Discern, Divaa, Divalprid, Divalpro, Divalproex, Elival, Epilex, Epival, Genval, Kayval, Napilex, Proval, Sezex, Sodaval, Sodijet, Spikalon, Trival, Valance, Valcontin, Valporate, Valporil, Valric, Valtril, Valvo, Velpo, Velze

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Also known as: Divalproex


Valop is a perfect remedy in struggle against seizure disorders. Valop acts by increasing the amount of a certain natural substance in the brain. Valop is also known as Valproate semisodium, Divalproex sodium, Valproic acid, Divaa. It is anticonvulsant. Generic name of Valop is Divalproex Sodium. Brand names of Valop are Valop, Valop ER, Valop Sprinkles.


Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Drink plenty of water while you are taking this medication. Your dose may need to be changed if you do not get enough fluids each day.

Swallow the capsule or tablet whole and do not crush, chew, break, or open it.

If you cannot swallow a sprinkle capsule whole, open it and sprinkle the medicine into a spoonful of pudding or applesauce. Swallow the mixture right away. Do not save it for later use.

You may need frequent blood tests.

If you need surgery, tell the surgeon ahead of time that you are using Valop ER.

In case of emergency, wear or carry medical identification to let others know you use Valop ER.

Do not stop using Valop ER suddenly, even if you feel fine. Stopping suddenly may cause a serious, life-threatening type of seizure. Follow your doctor's instructions about tapering your dose.

Store at room temperature away from moisture and heat.

Detailed Valop ER dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of reach of children.

Side effects

The most common side effects associated with Valop are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Valop Sprinkles if you are allergic to it, or if you have:

liver disease; a urea cycle disorder; or a genetic mitochondrial (MYE-toe-KON-dree-al) disorder such as Alpers' disease or Alpers-Huttenlocher syndrome, especially in a child younger than 2 years old.

Valop Sprinkles can cause liver failure that may be fatal, especially in children under age 2 and in people with liver problems caused by a genetic mitochondrial disorder.

Tell your doctor if you have ever had:

liver problems caused by a genetic mitochondrial disorder; depression, mental illness, or suicidal thoughts or actions; or a family history of a urea cycle disorder or infant deaths with unknown cause.

Some people have thoughts about suicide while taking Valop Sprinkles. Your doctor will need to check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Using Valop Sprinkles during pregnancy may increase the risk of serious birth defects that can develop early in pregnancy, even before you know you are pregnant. Using this medicine during pregnancy can also affect cognitive ability (reasoning, intelligence, problem-solving) later in your child's life. However, having a seizure during pregnancy could harm both the mother and the baby.

If you take Valop Sprinkles for seizures or manic episodes: The benefit of preventing seizures or manic episodes may outweigh any risks posed by this medicine. There may be other medications that are safer to use during pregnancy. Do not start or stop taking this medicine without your doctor's advice.

Do not use Valop Sprinkles to prevent migraine headaches if you are pregnant or you could become pregnant.

If you are not pregnant, use effective birth control to prevent pregnancy while using Valop Sprinkles. Tell your doctor if you start or stop using hormonal contraception that contains estrogen (birth control pills, injections, implants, skin patches, and vaginal rings). Estrogen can interact with this medicine and make it less effective in preventing seizures.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

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